Articles | Open Access | DOI: https://doi.org/10.37547/tajas/Volume06Issue04-01%20

ILLUMINATING CANCER DETECTION: SPECTROSCOPY'S VITAL ROLE IN SCREENING AND DIAGNOSIS

Caoimhe Brennan , School of Physics, Dublin Institute of Technology, Kevin St, Dublin, Ireland

Abstract

This paper explores the pivotal role of spectroscopy in cancer screening and diagnosis, shedding light on its significance in early detection and accurate characterization of cancerous tissues. Spectroscopic techniques offer unique capabilities for non-invasive and real-time analysis of tissue composition, providing valuable insights into biochemical and structural alterations associated with cancer development. By leveraging the inherent molecular signatures of tissues, spectroscopy enables clinicians to identify abnormal changes indicative of cancer presence, facilitating timely intervention and improved patient outcomes. This review examines the principles, methodologies, and applications of spectroscopy in cancer detection across various modalities, including Raman spectroscopy, fluorescence spectroscopy, and infrared spectroscopy. Additionally, it discusses recent advancements, challenges, and future directions in harnessing spectroscopic technologies for enhanced cancer screening and diagnosis.

Keywords

Spectroscopy, cancer detection, screening

References

Ferlay, J.; Soerjomataram, I.; Ervik, M.; Dikshit, R.; Eser, S.; Mathers, C.; Rebelo, M.; Parkin, D.M.; Forman, D.; Bray, F. GLOBOCAN, 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11, 2013. International Agency for Research on Cancer Web site. Available online: http://globocan.iarc.fr (accessed on 24 November 2014).

Diem, M. Introduction to Modern Vibrational Spectroscopy; Wiley: New York, NY, USA, 1993.

Movasaghi, Z.; Rehman, S.; Rehman, I.U. Fourier Transform Infrared (FTIR) Spectroscopy of Biological Tissues. Appl. Spectrosc. Rev. 2008, 43, 134–179.

Movasaghi, Z.; Rehman, S.; Rehman, I.U. Raman Spectroscopy of Biological Tissues. Appl. Spectrosc. Rev. 2007, 42, 493–541.

Diem, M.; Mazur, A.; Lenau, K.; Schubert, J.; Bird, B.; Miljkovic, M.; Krafft, C.; Popp, J. Molecular pathology via IR and Raman spectral imaging. J. Biophotonics 2013, 6, 855–886.

Baker, M.J.; Trevisan, J.; Bassan, P.; Bhargava, R.; Butler, H.J.; Dorling, K.M.; Fielden, P.R.; Fogarty, S.W.; Fullwood, N.J.; Heys, K.A.; et al. Using Fourier transform IR spectroscopy to analyze biological materials. Nat. Protoc. 2014, 9, 1771–1791.

Ellis, D.I.; Cowcher, D.P.; Ashton, L.; O’Hagan, S.; Goodacre, R. Illuminating disease and enlightening biomedicine: Raman spectroscopy as a diagnostic tool. Analyst 2013, 138, 3871–3884.

Kendall, C.; Isabelle, M.; Bazant-Hegemark, F.; Hutchings, J.; Orr, L.; Babrah, J.; Baker, R.; Stone, N. Vibrational spectroscopy: A clinical tool for cancer diagnostics. Analyst 2009, 134, 1029–1045.

Nijssen, A.; Koljenovic, S.; Bakker Schut, T.C.; Caspers, P.J.; Puppels, G.J. Towards oncological application of Raman spectroscopy. J. Biophotonics 2009, 2, 29–36.

Kitchener, H.C.; Blanks, R.; Cubie, H.; Desai, M.; Dunn, G.; Legood, R.; Gray, A.; Sadique, Z.; Moss, S.; MAVARIC Trial Study Group. MAVARIC—A comparison of automation-assisted and manual cervical screening: A randomised controlled trial. Health Technol. Assess. 2011, 15, iii–iv, ix–xi. 1–170.

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How to Cite

Caoimhe Brennan. (2024). ILLUMINATING CANCER DETECTION: SPECTROSCOPY’S VITAL ROLE IN SCREENING AND DIAGNOSIS. The American Journal of Applied Sciences, 6(04), 01–06. https://doi.org/10.37547/tajas/Volume06Issue04-01