https://theamericanjournals.com/index.php/tajvswd <p>E-ISSN <strong>2689-0968</strong></p> <p>DOI Prefix <strong>10.37547/tajvswd</strong></p> <p>Started Year <strong>2019</strong></p> <p>Frequency <strong>BiMonthly</strong></p> <p>Language <strong>English</strong></p> <p>APC <strong>$250</strong></p> en-US <p><em>Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the <a href="https://creativecommons.org/licenses/by/4.0/"><strong>Creative Commons Attribution License 4.0 (CC-BY)</strong></a>, which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.</em></p> editor@theamericanjournals.com (The USA Journals) tech@theamericanjournals.com (John Mike) Sat, 01 Mar 2025 09:02:24 +0000 OJS 3.3.0.7 http://blogs.law.harvard.edu/tech/rss 60 https://theamericanjournals.com/index.php/tajvswd/article/view/5917 <p>Senecavirus A (SVA) and Foot-and-Mouth Disease Virus (FMDV) are significant viral pathogens that cause major economic losses in livestock, particularly in pigs and cattle. This study investigates the inhibitory effects of bovine lactoferricin-lactoferrampin (bLFcin-LFamp) peptides on SVA and FMDV, delivered through recombinant Lactobacillus oral treatment in mice. The peptides' antiviral activity was evaluated in vitro and in vivo, with Lactobacillus engineered to express bLFcin-LFamp as a delivery vehicle. The results demonstrated that the recombinant Lactobacillus significantly reduced viral replication and clinical symptoms in mice infected with both SVA and FMDV. This study suggests that bLFcin-LFamp peptides, when delivered via oral Lactobacillus treatment, represent a promising therapeutic strategy for controlling viral infections in livestock.</p> Dr. Feng Hua Copyright (c) 2025 Dr. Feng Hua https://creativecommons.org/licenses/by/4.0 https://theamericanjournals.com/index.php/tajvswd/article/view/5917 Sat, 01 Mar 2025 00:00:00 +0000