https://theamericanjournals.com/index.php/tajvswd/issue/feedThe American Journal of Veterinary Sciences and Wildlife Discovery2025-03-01T14:17:18+00:00The USA Journalseditor@theamericanjournals.comOpen Journal Systems<p>E-ISSN <strong>2689-0968</strong></p> <p>DOI Prefix <strong>10.37547/tajvswd</strong></p> <p>Started Year <strong>2019</strong></p> <p>Frequency <strong>BiMonthly</strong></p> <p>Language <strong>English</strong></p> <p>APC <strong>$250</strong></p>https://theamericanjournals.com/index.php/tajvswd/article/view/5917Antiviral effects of bovine lactoferricin-lactoferrampin delivered via recombinant lactobacillus on senecavirus a and foot-and-mouth disease virus in mice2025-03-01T14:17:18+00:00Dr. Feng Huafeng@theamericanjournals.com<p>Senecavirus A (SVA) and Foot-and-Mouth Disease Virus (FMDV) are significant viral pathogens that cause major economic losses in livestock, particularly in pigs and cattle. This study investigates the inhibitory effects of bovine lactoferricin-lactoferrampin (bLFcin-LFamp) peptides on SVA and FMDV, delivered through recombinant Lactobacillus oral treatment in mice. The peptides' antiviral activity was evaluated in vitro and in vivo, with Lactobacillus engineered to express bLFcin-LFamp as a delivery vehicle. The results demonstrated that the recombinant Lactobacillus significantly reduced viral replication and clinical symptoms in mice infected with both SVA and FMDV. This study suggests that bLFcin-LFamp peptides, when delivered via oral Lactobacillus treatment, represent a promising therapeutic strategy for controlling viral infections in livestock.</p>2025-03-01T00:00:00+00:00Copyright (c) 2025 Dr. Feng Hua