The American Journal of Medical Sciences and Pharmaceutical Research

CANCER DRUG SENSITIVITY THROUGH GENOMIC DATA: INTEGRATING INSIGHTS FOR PERSONALIZED MEDICINE IN THE USA HEALTHCARE SYSTEM

Ekramul Hasan — 2024-12-11

Despite the significant progress in cancer genomics in America, there is still a noteworthy gap regarding genomic markers that predict drug sensitivity which presents a major obstacle to personalized oncology care. Tumors This research project aims to identify a set of genetic variations or mutations that influence the individual response of a cancer patient to certain drugs. This study also aims to develop machine learning models that can analyze a patient's genomic data to predict their likely response to different therapies. This study utilized the Genomic of Drug Sensitivity in Cancer (GDSC). The GDSC dataset is a very valued resource in therapeutic biomarker discovery in cancer research. This dataset combined drug response data with genomic profiles of cancer cell lines, enabling investigations into the relationship between genetic features and drug sensitivity. The main task associated with this dataset was to predict drug sensitivity, measured as IC50 values, from genomic features of cancer cell lines. Several accredited and proven Machine Learning algorithms were utilized in the study, particularly, Linear Regression, Ridge Regression, and SGD Regression. The most important regression model evaluation metrics deployed in a drug sensitivity prediction included the Mean Squared Error- MSE, Root Mean Squared Error- RMSE, and Mean Absolute Error- MAE. The Ridge Regression model outperformed the Linear Regression and the SGD algorithm, particularly, the Ridge Regression model captured excellently the hidden trends in the data much better compared to the other two models. Predictive analytics can significantly enhance clinical decision-making in the USA by providing health professionals with data-driven insights into the best available treatment options. As patient complexity and treatment options continue to grow, such models will help clinicians choose the most appropriate interventions for individual patients, informed by historical data on their disease course and other individual patient factors, including genetic profiling and comorbid status.

BASED ON THE SURVEY RESULTS, AN ASSESSMENT OF MILITARY PERSONNEL RESPONDENTS' AWARENESS OF HEALTH ISSUES (KNOWLEDGE, PROACTIVITY, AND COMPETENCE) WAS CONDUCTED

R.R. Khasanov — 2024-12-07

The daily routine of military personnel, which reflects military discipline, includes specific features related to eating habits, conditions, and increased professional workloads. Along with stress and psychological strain, the prevalence of harmful habits among military personnel is notably higher compared to the general population [2.13]. This, in turn, creates conditions for the development of decompensation in individuals suffering from any chronic non-communicable diseases, exacerbating existing pathology.

HARNESSING THE POWER OF HERBAL ANTIOXIDANTS IN DENTAL HEALTH

Vineet Bhatt — 2024-12-01

Herbal antioxidants, derived from plants with natural compounds such as polyphenols, flavonoids, and carotenoids, have gained considerable attention for their therapeutic potential in various health fields, including dentistry. This mini-review explores the role of herbal antioxidants in enhancing oral health by addressing oxidative stress, reducing inflammation, and promoting tissue regeneration in the oral cavity. Oxidative stress has been implicated in the development of several dental conditions, such as periodontal disease, tooth decay, and oral cancers. Herbal antioxidants, including extracts from green tea, turmeric, ginger, and aloe vera, offer promising adjuncts to conventional dental treatments by modulating oxidative damage, protecting against microbial infections, and promoting wound healing in oral tissues. The review discusses the mechanisms through which these herbal agents work, their clinical applications in preventive and therapeutic dentistry, and their potential benefits in reducing the side effects of conventional dental treatments. Despite the promising results, further clinical studies and trials are needed to validate their efficacy and safety in routine dental practice. This review aims to highlight the growing interest in herbal antioxidants as natural alternatives for improving oral health and their future applications in dental therapeutics.

TREATMENT OF BILATERAL CHRONIC CALCANEAL WOUNDS ASSOCIATED WITH OSTEOMYELITIS AND INFECTION OF THE LEFT CALCANEAL TENDON USING THE FIGUEIREDO TECHNIQUE IN A DIABETIC PATIENT: A CASE REPORT

Leandro Azevedo de Figueiredo — 2024-12-13

Among the most important complications of Diabetes Mellitus is the diabetic foot. Currently, wound treatment is based on surgical debridement and serial dressings.

However, controlling the evolution of ulcerations is difficult due to the patient's systemic conditions, recurrent infections in the lesions and the association with osteomyelitis and deep soft tissue infection, often requiring hospitalization for surgery and intravenous antibiotic therapy.

The aim of this study is to report a case of surgical treatment with the Figueiredo Technique (FT) of bilateral chronic wounds on the calcaneus, associated with osteomyelitis and infection of the left calcaneal tendon, in a diabetic patient.

FEATURES OF HEART RATE VARIABILITY (HRV) AND INDICATORS OF DAILY BLOOD PRESSURE MONITORING (ABPM) IN PATIENTS WITH DIABETES MELLITUS WITH DIFFERENT PATHOGENETIC SUBTYPES OF ISCHEMIC STROKE

Muso Boltayevich Urinov — 2024-12-10

Heart rate variability (HRV) and daily blood pressure monitoring (ABPM) serve as critical tools in assessing cardiovascular and autonomic regulation in patients with ischemic stroke (IS). In individuals with concomitant type 2 diabetes mellitus (T2DM), these parameters may differ significantly, influenced by the interplay between the systemic metabolic dysregulation of T2DM and cerebrovascular pathology. This study explores HRV and ABPM characteristics in 256 patients with IS, divided into groups based on the presence of T2DM, to delineate the impacts of diabetes on stroke-related cardiovascular dysregulation.

PERCEPTION AND MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS AMONG GENERAL DENTISTS IN BANGALORE

Dr. Divya Nathan — 2024-12-02

Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder of the oral mucosa, characterized by progressive fibrosis, limited mouth opening, and oral mucosal changes, commonly linked to the consumption of areca nut and tobacco products. The early detection and management of OSMF are crucial for preventing its progression to oral cancer. This study aimed to assess the perception, awareness, and management practices regarding OSMF among general dentists in Bangalore. A cross-sectional survey was conducted among general dentists in various dental practices across the city, using a structured questionnaire to evaluate their knowledge of OSMF’s clinical features, diagnostic methods, treatment options, and preventive strategies. The findings revealed a moderate level of awareness regarding the disease, with significant variations in knowledge about advanced diagnostic and treatment modalities. While most dentists recognized the importance of early detection, the management approaches varied, with many resorting to symptomatic treatments rather than comprehensive, multidisciplinary interventions. The study highlights the need for enhanced continuing education and training for general dentists on the diagnosis, prevention, and management of OSMF to improve patient outcomes and reduce the incidence of oral cancers associated with the condition.

OPTIMIZING SKIN CANCER DETECTION IN THE USA HEALTHCARE SYSTEM USING DEEP LEARNING AND CNNS

Md Nasiruddin — 2024-12-21

Skin cancer is among the most prevalent cancers in the USA, with millions of new cases reported each year. The two main types of skin cancer include aggressive, life-threatening melanoma and less lethal, though potentially very morbid if left unattended, non-melanoma types: basal cell carcinoma and squamous cell carcinoma. The chief aim of this research project is to devise, curate, and propose a deep-learning CNN methodology for skin cancer detection in the USA. The dataset for the current research project was retrieved from the Kaggle website, particularly, The ISIC 2016 Skin Cancer Dataset contained dermoscopic images that were used for skin cancer classification. In this dataset, there were 1271 images of two classes of skin cancer, namely Malignant and Benign. These images were then gathered from the ISIC archive. The dataset was then divided into a training set consisting of 1022 images and a test set consisting of 249 images. The CNN proposed for this work is a deep-learning architecture designed to address skin cancer detection through dermoscopic images. The model follows a sequential architecture with multiple layers dedicated to the extraction of hierarchical features from input images. To assess the performance of the CNN algorithm for skin cancer detection, several proven metrics are utilized, namely, accuracy, precision, recall, and F1-Score. The model obtained a very high precision, recall, and F1-score over all classes, with a general accuracy of 94% for this multi-class problem. This model was very good, both in precision since it correctly identifies the actual positive cases and in recall, where it does not have false positives. The developed proposed CNN model for skin cancer detection has great potential to support human clinical decision-making in all dermatology. This developed model automates the various analyses of dermoscopy images, hence acting as just an adjunct tool for active dermatologists, which shall enable fast and accurate skin lesion assay. Results have shown that this CNN can easily be integrated into diagnosis workflows in normal dermatological practice to offer a second opinion or even a pre-screening tool for dermatologists.

SURGICAL TREATMENT OF A CHRONIC ANKLE WOUND ASSOCIATED WITH OSTEOMYELITIS OF THE FIBULA, WITH THE FIGUEIREDO TECHNIQUE: A CASA REPORT

Leandro Azevedo de Figueiredo — 2024-12-13

Peripheral Obstructive Arterial Disease (PAD) is the obstruction of the peripheral arteries caused by atherosclerosis. Intermittent claudication is the main manifestation, in more advanced stages there may be ischemia and chronic wounds.

PAD is a relevant public health condition due to its high prevalence and impact on patients' quality of life, as well as the risk of disease progression, which can result in limb amputations due to infections and deep ulcerations, associated with serious systemic complications.

The aim of this study is to report a case of treatment with the Figueiredo Technique (FT) of a chronic left ankle injury due to Peripheral Arterial Occlusive Disease, associated with osteomyelitis of the fibula, in an elderly patient.

ANALYZING TRENDS AND DETERMINANTS OF LEADING CAUSES OF DEATH IN THE USA: A DATA-DRIVEN APPROACH

Saddam Hossain — 2024-12-13

The exponential escalation of the causes of death and their trends and determinants in the nation greatly define the health landscape of the United States. These causes of death, such as heart disease, cancer, chronic lower respiratory diseases, HIV &AIDS, accidents, and stroke, have been major public health concerns for many decades. Each condition represents broader societal and individual health challenges that include lifestyle choices, environmental factors, genetic predispositions, and healthcare accessibility. This research project aimed to use the data-driven approach in the exploration of these trends to understand the patterns and determinants underpinning mortality statistics. Using an expanded data set, the study presented leading causes of death; the pattern of variation by demographic factors, including age, sex, and race/ethnicity; and social, environmental, and behavioral determinants of those patterns. The datasets for our research project were retrieved from the Kaggle website, namely, "NCHS - Leading Causes of Death: United States" which was very informative regarding the major causes of death in the United States between the years 1999 and 2016. It was organized in such a way that one can analyze the trends; hence, it includes variables such as Cause of Death, such as heart disease and cancer, Year, State, Age-adjusted Death Rate, and Number of Deaths. Other demographic variables, like Sex and Race/Ethnicity, further allowed for even finer subgroups, which were very useful in highlighting disparities in health outcomes. The performances of the three machine learning models, Linear Regression, Random Forest, and XG-Boost, based on Mean Squared Error (MSE) and R-squared (R2) were evaluated. Retrospectively, XG-Boost outperformed the other models significantly for both MSE and R2. This therefore means that on this dataset, XG-Boost is the best model that can be used for the most accurate and reliable prediction. In that respect, advanced machine learning models, applied to mortality trends, provide deep insight into the underlying determinants. Large datasets comprising demographic, socioeconomic, and health-related variables are analyzed for patterns and correlations that may not be obvious in traditional statistical methods. Model predictions can indicate future trends in mortality by highlighting populations at high risk and locations. Data-driven models hold monumental implications in public health through the provision of insights into the trends and determinants of mortality, besides including possible interventions.