Meaning Of Respiratory Mycoplasma Infection In Children With Bronchial Asthma

Meaning and role of mycoplasma infection for children with bronchial asthma small studied. By us was inspected 39 children with BA in age from 2 to 14, from them 27 (69,2%) boys and 12 (30,8) girls. Obtained data from PChR testing is shown: among the children of patients with BA for 33,3% (13/39) patients found out M. pneumoniae.; for 66,7% (26/39) patients and for all children of control group M. pneumoniae. it is not discovered (table. № 1). For children in a range 2-5, the more than half (53,8%) of children-asthmatics was got positive results of PChR; among the investigated children in age 6-14, only at 46,2% patients had M. pneumonia. Except it, among patients with BA, for 69,2% boys and 31% girls made the positive result of PChR, and correlation of sexes was made by 2,2: 1.


INTRODUCTION
From data of results of analysis of modern literature in the whole world in the last few years, a tendency is marked to the increase of morbidity bronchial asthma (BA) for children The American Journal of Medical Sciences and Pharmaceutical Research (ISSN -2689(ISSN - -1026) ) Published: December 29, 2020 | Pages: 47-54 Doi: https://doi.org/10.37547/TAJMSPR/Volume02Issue12-09IMPACT FACTOR 2020: 5. 286 OCLC -1121105510 obstruction and increasing bronchial reactivity [11,15,23].Wheezing (whistling breathing), shortness of breath, constraint in a breast, cough, products of sputum -clinical symptoms are characteristic for bronchial asthma.[11].
Flow BA for children related to the row of anatomical-physiological features: narrowest of road clearance of bronchial tubes, enhanceable vascularization of respiratory tracts, insufficient rigidity of thorax, elasticity of lungs, weak development of smooth musculature of bronchial tubes, hypersecretion of viscid mucus by gobled cages.Predominance of edema of mucous membrane, resulting in a selection mucuses in the road clearance of bronchial tubes above the spasm of smooth muscles, is another personal touch jf BA for children [15,23].
Causes different irritants of BA in children (atypical, viral infections, trigger factors) under their influence at any time can there is narrowing road clearance of bronchial tubes.In addition in pathogenesis of bronchial asthma, influences to difficult mixture of a few wellknown factors, such as genetic, ecological, dietary changes and professions, confessed as factors of predisposition to bronchial asthma [2,6].
In the last time, the scientists are spare large attention on a role different to the infection at BA in children.An infectious process can be provocateur, as a factor for the attack of bronchial spasmа, or sharp viral infection often become reason of intensifying of BA in children.Some infectious microorganisms (viruses, bacteria) considerably influences on the immune reaction of child, promotes secondary to infecting of respiratory tracts; increase of bronchial hyperreactivity and to development of bronchial spasm.Sick children with an atopic form of BA genetically predisposition to the persistent flow of some viral and atypical (intracellular) infections.In pathogenesis of BA the role of infection of respiratory tracts is great.And at intensifying they play not unimportant role.Lately role of atypical causative agents at BA for children (Chl.pneumoniae and M. pneumonia) began to be actively studied [5].
To date it is well-proven that M. pneumonia is one of basic causative agents of pneumonia for children [1,4,5,6,23].This insufficiently known infection can be primary reason of pneumonia for children or because of joining with a secondary infection causes the chronic fever of lungs.Values and role of mycoplasma infection in children with BA small studied, therefore study of role and value of mycoplasma infection in children with BA opens new ideas about the mechanism of development of BA in children.
The aim of our researches is a study of role of respiratory mycoplasma infection in intensifying of BA in children.

MAIN PART
By us was inspected 39 children with BA, in age of from 2 to 14, from them 27 (69,2%) boys and 12 (30,8%) girls.All children were on a planning inspection and treatment, in periods of 2019-2020-years on the base of child allergist and pulmonologist departments, at the Multi-field clinic of ТМА.The presence of atopy for family members and bronchial asthma are closely constrained.For children with BA domestic allergic anamnesis (it was educed for family members: atopic dermatitis, bronchial asthma, alimentary allergy) was burdened (р=0,05), as compared to control groups of the investigated children.

DISCUSSION
The got analyses of results showed, that for 35,9% children with BA family anamnesis is one of key risk factors development of BA.Burdened family anamnesis with atopic dermatitis too (as statistically meaningful (p=0,005)), plays a not insignificant role as risk factor for development of BA from child's age.This result was educed at 41,1% as compared to 13,6% in a control group.It is necessary to take into account, burdened family anamnesis and atopy, not only saved but also strengthens a flow BA and other atopic disease further.
An alimentary or food allergy is in family anamnesis, development matters by child's bronchial asthma.Research results show 17,9% of asthmatic patients as compared to 2,3% in a control group (р = 0,019).To talk it about that, children with a food allergy in 7,8 time were more often ill asthma, than themes, childrenasthmatics do not have a food allergy.
A food allergy also appeared the marker of weight of bronchial asthma.Results undertaken laboratory studies are determination of DNA of fragments of M.pneumoniae shows, statistical connection between bronchial asthma and MP infection (p 0,001).
At 33,3% of sick patients it was got positive reaction on the M.pneumoniae method of PChR, in a control group this index was made by 0,0%.
Sick children with the positive ПЦР result, as compared to the negative patients of M. pneumoniae, did not show to the association (p = 0,44, p = 0,64 and p = 0,19 accordingly).
Seasonal allergy (p = 0,02) and burdened domestic anamnesis, (p CONCLUSION Thus, taking the family history has a very large role, showed the presence of atopy (presence of bronchial asthma, atopic dermatitis and alimentary allergy) closely-coupled interface with bronchial asthma.M. pneumonia is closely related to bronchial asthma.She can be counted, as major risk factors at intensifying of bronchial asthma.Mycoplasma an infection aggravates a clinical flow BA in children, and in one season there were a few episodes of intensifying BA in children.A cough and wheeze in a breast are considered the major sign of M. pneumonia, but here in a roentgengraphy, defining not maybe.
Complaints of sick children with BA with positive and negative PChR answers in the presence of M. pneumonia. Table№2.
The American Journal of Medical Sciences and Pharmaceutical Research(ISSN -2689(ISSN - -1026)   )