Monitoring And Evaluation Of Hemodynamic Parameters During Anesthesia In Endocrine Surgery

The article presents the results of preoperative preparation, anesthesia and surgical treatment of patients operated on for non-toxic nodular goiter. A new approach to preoperative preparation for thyroid surgery is described. The effectiveness in the preoperative period of using the modified method of preoperative preparation using sibazon and droperidol and anesthesia with the use of ketamine and the advantages of this method compared with other methods of general anesthesia are shown.


INTRODUCTION
Currently, there is a steady increase in the number of thyroid diseases worldwide. A significant number of population living in the territory of Uzbekistan have obvious or hidden functional disorders of the thyroid gland [6].
Diffuse non -toxic goiter is the most common pathology, which takes up to 60% of all cases of thyroid disease. In this pathology, the functions of the central nervous system and endocrine system, blood circulation and

Monitoring And Evaluation Of Hemodynamic Parameters During Anesthesia In Endocrine Surgery
The American Journal of Medical Sciences and Pharmaceutical Research (ISSN -2689-1026) Published: December 28, 2020 | Pages: 40-46 Doi: https://doi.org/10.37547/TAJMSPR/Volume02Issue12-08 IMPACT FACTOR 2020: 5. 286 OCLC -1121105510 respiration, liver and kidneys, immunity and metabolism are impaired [5]. Often, this type of thyroid disease is the leading one in the group of endocrine diseases, the main method of treatment for which is surgery. It should be considered that during operations on the thyroid gland, it is important to use the optimal method of anesthesia, which would prevent the manifestations of pathological reactions associated with the nature of the main and concomitant diseases. The high risk of intraand postoperative complications associated with the anatomical features of the surgical intervention area justifies the relevance of the problem of optimizing the anesthetic allowance for thyroid surgery [2].
Analyzing of currently used methods of general anesthesia for thyroid diseases, we can assume that not all of them do fully prevent the negative effects and reactions that occur in the body to surgical stress and have many other serious drawbacks. These include: the use of narcotic analgesics and anesthetics, postoperative respiratory depression and rapid cessation of analgesia in the early postoperative period, a number of adverse hemodynamic changes at traumatic stages of surgery [1].
When choosing an anesthetic to maintain anesthesia for thyroid disease, the characteristics of the psychological and somatic status of patients, the nature of the influence of the disease on the circulatory system and the functional state of parenchymal organs, and the presence of concomitant diseases are guided [3].
Surgical treatment of thyroid pathology, including goiter under General anesthesia using neuroleptanalgesia (NLA) in the most traumatic moments of the operation is often accompanied by dangerous circulatory disorders in the form of tachycardia, arterial hypertension, and heart rhythm disorders [3]. If the patient also has concomitant diseases (CVS diseases and diabetes mellitus), then the complication during anesthesia becomes critical. In modern practical anesthesiology, much attention is paid to the blockage of pathological impulsion, which occurs under the influence of surgical trauma of the afferent and central nervous system during the medical preparation of the patient in the preoperative period.
Anesthesiology does not yet know ideal and universal solutions to the problem of protecting the patient from surgical aggression. The most reasonable approach is a multi-modal approach that implies a multilevel, multi-purpose antinociception, in which the maximum effect (due to synergy or summation of action) is combined with a minimum of side effects [6].
The appearance of modern drugs for anesthesia and improvement of surgical treatment results at the current stage of development of endocrine surgery is seen in the further improvement of preoperative preparation and intraoperative anesthesia.

OBJECTIVE
To choose the effective method of preoperative preparation and types of anesthesia on thyroid gland surgery. The following operations were performed: strumectomy (14 cases), hemistrumectomy (24 cases), hemistrumectomy with isthmus removal (7 cases), extremely subtotal-subfacial strumectomy (11 cases). The average duration of the operation is 50 ± 13 minutes. The first group (control group -n=34) -patients who underwent traditional preoperative therapy and standard anesthesia. Group II (study group -n=38) -patients whose preoperative preparation was performed using a modified method with the use of sibazone and droperidol. In group 1, premedication was performed on the operating

RESEARCH RESULT
Our studies showed that the initial parameters of сentral hemodynamics in patients in both groups did not significantly differ from each other (tables 1., 2.). conducting a step-by-step monitoring of changes in central hemodynamics, we found that patients in the control group already at the preoperative stage, before induction into anesthesia, there was a significant increase in blood pressure, SBP, DBP, ABP and heart rate (p<0.05) heart rate by 3.9% (p<0.05) compared to the first stage. After premedication, the SBP is lower than the initial figures by 3.4% (p<0.01), DBP by 5.3% (p<0.001), ABP by 4.5% (p<0.001), heart rate by 4.6% (p<0.05). These changes in central hemodynamic parameters are positive and are due to the stabilization of the neurovegetative system against the background of the use of sibazone and droperidol, since admission to the hospital itself is already a stressful situation for most patients (table 2). By analyzing the level of preoperative sedation, it was found that in 80% of patients in the control group, the effect of premedication was unsatisfactory, it was expressed in emotional tension, anxiety, and fear of surgery.
In the study group, the level of preoperative sedation was adequate in 100 % of cases.
At the traumatic stage of the operation, there was a significant increase in the average blood pressure values in group 1 by 19.2 % (p < 0.05), in group 2-by 12 % (p < 0.05). Heart rate in the most traumatic stages of surgery increased by 15.6 % (p <0.05) in group 1 and by 16 % (p<0.05) in group 2. These changes indicated a hyperdynamic reaction of the cardiovascular system, activation of the neuro-vegetative system. There were no significant differences between the two groups at this stage of the study (p>0.05). SBP returned to normal in group 2 after the operation, and in group 1 only by the first day after the operation. In the postoperative period, the heart rate remained stable.
In group 1, the glucose level increased during the traumatic stage of the operation, reaching a maximum by the end of the operation (6.98 mmol/l; p < 0.05), and returned to normal only on the first day. In group 2, the blood glucose concentration was normalized by the first day after surgery.
The level of TSH and T3 in both groups remained within the reference values at all stages of the study, no significant differences in these indicators were found in the comparison groups (p > 0.05). In all groups, SpO remained at the normal level of 97-99% during anesthesia and in the early postoperative period.

CONCLUSIONS
1. Patients operated on for thyroid diseases, in the intraoperative period, undesirable hemodynamic, vegetative and neuroendocrine reactions of the body occur, which negatively affect the course of the perioperative period and the anesthetic allowance. 2. The use of a modified method of preoperative preparation with the use of sibazone and droperidol in patients operated on for thyroid diseases helps to reduce emotional stress, providing an adequate level of preoperative sedation, allows you to optimize the anesthetic effects, minimize the negative effects and doses of anesthetics. 3. The use of general anesthesia with fentanyl and droperidol does not fully block nociceptive impulses, which indicates insufficient protection of the patient from surgical aggression, characterized by instability of hemodynamics, preservation of endocrine and metabolic changes. The addition of ketamine to General anesthesia and the use of a modified method of preoperative preparation can reduce the dose of opioids, stabilize hemodynamics and ensure safety of the preoperative period.